尿激酶（UK）是从人新鲜尿液中提取的一种溶栓剂。它可以激活纤溶酶原为纤溶酶，随后水解纤维蛋白和溶解血栓。 该产品主要用于治疗急性心肌梗死，急性脑血栓，脑血管闭塞，外周动静脉血栓，视网膜中央静脉血栓和其他由于新血凝块的形成而引起的梗死性疾病。
浩然生物可以供应以下规格的UK原料。也可以根据客户的需求准备其他规格的产品。
|
性状 |
白色或类白色无定形粉末 |
|
鉴别 |
符合规定 |
|
活性 |
不少于80,000 IU/mg |
|
比活 |
不少于120,000 IU/mg蛋白质 |
|
溶液澄清度 |
澄清 |
|
凝血质样物质 |
不少于150 IU/ml |
|
高分子量尿激酶 |
不少于90% |
|
细菌内毒素 |
不超过1.0 EU /10,000 IU |
|
异常** |
阴性 5000 IU/0.5ml/鼠 |
|
人类免疫缺陷病毒I型和II型抗原 |
阴性 |
|
乙肝病毒表面抗原 |
阴性 |
|
丙肝病毒抗体 |
阴性 |
Urokinase (UK) is a thrombolytic agent extracted from human fresh urine. It can activate plasminogen to plasmin, with the subsequent hydrolysis of fibrin and dissolution of thrombi.
This product is mainly used in the treatment of acute myocardial infarction, acute cerebral thrombosis, occlusion of cerebral blood vessel, peripheral arteriovenous thrombi, central retinal arteriovenous thrombi and other infarction diseases due to freshly formed clot
Haoran Biopharma can supply bulk UK with the following specifications. Products of various specifications can also be prepared according to customers' requests.
|
Appearance |
White or almost white, amorphous powder |
|
Identification |
Identified |
|
Activity |
Not less than 80,000 IU/mg |
|
Specific activity |
Not less than 120,000 IU/mg protein |
|
Clarity of solution |
Clear |
|
Thromboplastic contaminants |
Not less than 150 IU/ml |
|
HMW-Urokinase |
Not less than 90% |
|
Bacterial endotoxins |
Not more than 1.0 EU /10,000 IU |
|
Abnormal toxicity |
Negative at 5000 IU/0.5ml/mouse |
|
HIV I+II antibody |
Negative |
|
Hepatitis B surface antigen |
Negative |
|
HCV antibodies |
Negative |
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