中试型微流控制备仪

简介

Brief introduction

MPE-P1型微流控制备仪，是中试型制备系统，可用于脂质纳米颗粒LNP、聚合物纳米颗粒、脂质体Liposome、微乳Emulsion等微纳米制剂中试规制备工艺开发，助力核酸药物、小分子药物DDS系统的产业化研究。设备采用集成式触屏操作，系统配置批次记录、数据导出等功能，便捷高效。MPE-P1中试型微流控制备仪，支持高浓度和高流速下LNP、Liposome等微粒的制备，结果稳定，重现性高，可为生产放大提供详实、可靠、全面的工艺数据。

功能应用：

Functional application

• 化学药品脂质体（Liposome）制备，如多柔比星脂质体、伊立替康脂质体等； 

Preparation of chemical  liposomes, such as doxorubicin liposomes, iritecan liposomes, etc;

• 生物类脂质纳米颗粒颗粒（LNP）制备，如mRNA脂质体、siRNA-LNP等； 

Preparation of biological lipid nanoparticles (LNP), such as mRNA liposomes, siRNA LNP, etc;

• 聚合物纳米颗粒/微球等制备，如PLGA微球、PEG-PLGA纳米颗粒等； 

Preparation of polymer nanoparticles / microspheres, such as PLGA microspheres and peg-plga nanoparticles;

• 乳剂（Emulsion）的制备，如疫苗佐剂、脂肪乳制剂等； 

Preparation of emulsion, such as vaccine adjuvant, fat emulsion preparation, etc;

• 有机/无机纳米粒，如金纳米等； 

Organic / inorganic nanoparticles, such as gold nanoparticles;

• 其他相关微纳米制剂。

Other related micro nano preparations.

技术参数

Technical Parameter

微流控芯片 

Microfluidic Chips

微流控芯片是基于应用工艺的定制型特殊流道结构部件，其通道结构和尺寸均与项目工艺需求相结合，属定制型结构件。具体来说可实现以下四种功能：

Microfluidic chip is a customized special channel structure component based on the application process. Its channel structure and size are combined with the process requirements of the project. Specifically, the following four functions can be realized:

• 两相的混合、乳化；

Mixing and emulsification of two phases;

• 微粒形成后的孵育；

Incubation after particle formation;

• 微粒形成后的粒径控制；

Particle size control after particle formation;

•  二次混合或乳化。

Secondary mixing or emulsification after particle formation.